methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

Base Information

Chemical Name:methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate
CAS No.:1199804-96-0
Molecular Formula:C₁₅H₁₀FIN₄O₂
Molecular Weight:424.173
Hs Code.:

Synonyms:methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

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Chemical Property of methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

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Technology Process of methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

There total 1 articles about methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1199804-95-9
methyl 5-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

: 1199804-96-0
methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

Guidance literature:: With N-iodo-succinimide; trifluoroacetic acid; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/ml5001239

Reference yield: 82.0%

: 1199804-96-0
methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

: 106-54-7
p-Chlorothiophenol

: 1199804-68-6
methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

Guidance literature:: p-Chlorothiophenol; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.25h;

methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate; With copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 150 ℃;
DOI:10.1021/ml5001239

Reference yield:

: 1199804-96-0
methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

: 1199802-19-1
2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0.25 h / 20 °C

1.2: 0.17 h / 150 °C / Microwave irradiation

2.1: tetrahydrofuran / 20 °C

With sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;