methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

Base Information

• Chemical Name: methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate
• CAS No.: 1199804-68-6
• Molecular Formula: C₂₁H₁₄ClFN₄O₂S
• Molecular Weight: 440.885
• Mol file: 1199804-68-6.mol

Synonyms:methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

Chemical Property of methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

There total 1 articles about methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate (1199804-96-0) + p-Chlorothiophenol (106-54-7) → methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate (1199804-68-6)

Guidance literature:

p-Chlorothiophenol; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.25h;

methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate; With copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 150 ℃;

DOI:10.1021/ml5001239

Reference yield: 43.0%

methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate (1199804-68-6) + methylmagnesium bromide (75-16-1) → 2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol (1199802-19-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.333333h;

DOI:10.1021/ml5001239

Reference yield:

methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate (1199804-68-6) → C20H14ClFN6OS

Guidance literature:

With hydrazine; In ethanol; at 80 ℃;

upstream raw materials:

methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

p-Chlorothiophenol

Downstream raw materials:

2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol

2-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-5-(1,3,4-oxadiazol-2-yl)pyrazine