4-chloro-3-[(4-chlorophenyl)thio]-2-methyl-1H-pyrrolo[3,2-c]pyridine-1-acetic acid 1,1-dimethylethyl ester

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Chemical Name:4-chloro-3-[(4-chlorophenyl)thio]-2-methyl-1H-pyrrolo[3,2-c]pyridine-1-acetic acid 1,1-dimethylethyl ester
CAS No.:871327-76-3
Molecular Formula:C₁₈H₁₆Cl₂N₂O₂S
Molecular Weight:395.309
Hs Code.:

Synonyms:4-chloro-3-[(4-chlorophenyl)thio]-2-methyl-1H-pyrrolo[3,2-c]pyridine-1-acetic acid 1,1-dimethylethyl ester

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Chemical Property of 4-chloro-3-[(4-chlorophenyl)thio]-2-methyl-1H-pyrrolo[3,2-c]pyridine-1-acetic acid 1,1-dimethylethyl ester

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Technology Process of 4-chloro-3-[(4-chlorophenyl)thio]-2-methyl-1H-pyrrolo[3,2-c]pyridine-1-acetic acid 1,1-dimethylethyl ester

There total 8 articles about 4-chloro-3-[(4-chlorophenyl)thio]-2-methyl-1H-pyrrolo[3,2-c]pyridine-1-acetic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 854018-88-5
4-chloro-3-(4-chloro-phenylsulfanyl)-2-methyl-1H-pyrrolo[3,2-c]pyridine

: 105-36-2
ethyl bromoacetate

: 871327-76-3
4-chloro-3-[(4-chlorophenyl)thio]-2-methyl-1H-pyrrolo[3,2-c]pyridine-1-acetic acid 1,1-dimethylethyl ester

Guidance literature:: 4-chloro-3-(4-chloro-phenylsulfanyl)-2-methyl-1H-pyrrolo[3,2-c]pyridine; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

ethyl bromoacetate; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 234108-74-8
(2-chloro-3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester

: 871327-76-3
4-chloro-3-[(4-chlorophenyl)thio]-2-methyl-1H-pyrrolo[3,2-c]pyridine-1-acetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / -78 - 20 °C

1.2: 72 h / -78 - 20 °C

2.1: copper(l) iodide / DMF (N,N-dimethyl-formamide) / 24 h / 20 - 120 °C

3.1: toluene; acetonitrile / 72 h / 20 °C

4.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

With sodium hydride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); toluene; acetonitrile;

Reference yield:

: 854018-86-3
tert-butyl (2-chloro-3-prop-1-yn-1-ylpyridin-4-yl)carbamate

: 871327-76-3
4-chloro-3-[(4-chlorophenyl)thio]-2-methyl-1H-pyrrolo[3,2-c]pyridine-1-acetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide / DMF (N,N-dimethyl-formamide) / 24 h / 20 - 120 °C

2: toluene; acetonitrile / 72 h / 20 °C

3: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

With sodium hydride; copper(l) iodide; In DMF (N,N-dimethyl-formamide); toluene; acetonitrile;