2-Ethoxy cinchoninic acid

Base Information

• Chemical Name: 2-Ethoxy cinchoninic acid
• CAS No.: 5467-62-9
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.224
• Hs Code.: 2933499090
• Mol file: 5467-62-9.mol

Synonyms:Cinchoninicacid, 2-ethoxy- (7CI,8CI); NSC 25660

Chemical Property of 2-Ethoxy cinchoninic acid

Chemical Property:

• Vapor Pressure: 3.96E-06mmHg at 25°C
• Boiling Point: 370°Cat760mmHg
• Flash Point: 177.6°C
• PSA: 59.42000
• Density: 1.279g/cm³
• LogP: 2.33170

Purity/Quality:

99%min ^*data from raw suppliers

2-Ethoxyquinoline-4-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethoxy cinchoninic acid

There total 4 articles about 2-Ethoxy cinchoninic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

→ 2-ethoxyquinoline-4-carboxylic acid (5467-62-9)

Guidance literature:

Reference yield:

2-phenylsulfanyl-quinoline-4-carboxylic acid ethyl ester (6949-89-9) + sodium ethanolate (141-52-6) + ethyl acetate (141-78-6) → 2-ethoxyquinoline-4-carboxylic acid (5467-62-9) + 1-(2-phenylsulfanyl-[4]quinolyl)-ethanone (859982-74-4)

Guidance literature:

With benzene; Erwaermen des Reaktionsgemisches mit wss.Schwefelsaeure;

DOI:10.1021/ja01213a043

Reference yield:

2-ethoxy-quinoline-4-carboxylic acid ethyl ester (5471-39-6) → 2-ethoxyquinoline-4-carboxylic acid (5467-62-9)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; for 0.5h; Ambient temperature;

DOI:10.1021/jm00104a016

upstream raw materials:

2-phenylsulfanyl-quinoline-4-carboxylic acid ethyl ester

sodium ethanolate

ethyl acetate

2-ethoxy-quinoline-4-carboxylic acid ethyl ester

Refernces

• 1、 Hayashi, Hiroaki,Miwa, Yoshikazu,Miki, Ichiro,Ichikawa, Shunji,Yoda, Noboyuki,et al.. "5-HT3 Receptor Antagonists. 1. New Quinoline Derivatives". . p. 4893 - 4902. Retrieved 2007/10/02.