tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate

Base Information

Chemical Name:tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate
CAS No.:1404097-57-9
Molecular Formula:C₁₉H₂₄F₄N₂O₄
Molecular Weight:420.404
Hs Code.:

Synonyms:tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate

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Chemical Property of tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate

Chemical Property:

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Technology Process of tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate

There total 1 articles about tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.9%

: 70126-48-6
3-(1',1',2',2'-tetrafluoroethoxy)-benzoic acid

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1404097-57-9
tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 - 25 ℃;
DOI:10.1021/jm301164y

Reference yield:

: 1404097-57-9
tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate

: 1404098-53-8
N-(1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 3 h / 0 - 25 °C

2: potassium carbonate / ethanol; water / 25 - 80 °C

3: sodium tetrahydroborate / methanol / 0.5 h / 0 - 60 °C

4: hydrogenchloride / water; acetone / 0.5 h

5: triethylamine / dichloromethane / 20 - 25 °C

6: ethanol; water / 80 °C / Reflux

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm301164y

Reference yield:

: 1404097-57-9
tert-butyl (1-(3-(1,1,2,2-tetrafluoroethoxy)benzoyl)piperidin-4-yl)carbamate

: 1404097-61-5
C₂₂H₂₂F₄N₂O₃

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 3 h / 0 - 25 °C

2: potassium carbonate / ethanol; water / 25 - 80 °C

3: sodium tetrahydroborate / methanol / 0.5 h / 0 - 60 °C

4: hydrogenchloride / water; acetone / 0.5 h

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; In methanol; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm301164y