4-Piperidinecarboxylicacid,4-hydroxy-,methylester(9CI)

Base Information

• Chemical Name: 4-Piperidinecarboxylicacid,4-hydroxy-,methylester(9CI)
• CAS No.: 767265-77-0
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.185
• Hs Code.: 2933399090
• Mol file: 767265-77-0.mol

Synonyms:4-Hydroxy-4-piperidinecarboxylicacid methyl ester; Methyl 4-hydroxypiperidine-4-carboxylate

Chemical Property of 4-Piperidinecarboxylicacid,4-hydroxy-,methylester(9CI)

Chemical Property:

• Boiling Point: 229.5±40.0 °C(Predicted)
• PKA: 12.77±0.20(Predicted)
• PSA: 58.56000
• Density: 1.174±0.06 g/cm3(Predicted)
• LogP: -0.39730
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-Hydroxypiperidine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinecarboxylicacid,4-hydroxy-,methylester(9CI)

There total 6 articles about 4-Piperidinecarboxylicacid,4-hydroxy-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ methyl 4-hydroxy-4-piperidinecarboxylate (767265-77-0)

Guidance literature:

Reference yield: 91.0%

4-hydroxy-4-(methoxycarbonyl)-1-(phenylmethyl)piperidine (60437-30-1) → methyl 4-hydroxy-4-piperidinecarboxylate (767265-77-0)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; at 20 ℃; for 18h; under 2327.23 Torr;

Reference yield:

methanol (67-56-1) + 1-benzyl-4-hydroxypiperidine-4-carboxylic acid (59119-18-5) → methyl 4-hydroxy-4-piperidinecarboxylate (767265-77-0)

Guidance literature:

With hydrogen; palladium(II) hydroxide; at 20 ℃; for 6h; Product distribution / selectivity;

upstream raw materials:

4-hydroxy-4-(methoxycarbonyl)-1-(phenylmethyl)piperidine

1-benzyl-4-hydroxypiperidine-4-carboxylic acid

1-benzyl-4-hydroxypiperidine-4-carbonitrile

methanol

Downstream raw materials:

2-(4-hydroxy-4-(hydroxymethyl)piperidin-1-yl)-4-(4-methoxy-3-(trifluoromethyl)phenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

4-benzyloxy-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

tert-butyl 4-(benzyloxy)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

3-[4-(benzyloxy)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate hydrochloride

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