2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione

Base Information

Chemical Name:2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione
CAS No.:183433-90-1
Molecular Formula:C₁₉H₂₁NO₃
Molecular Weight:311.381
Hs Code.:

Synonyms:2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione

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Chemical Property of 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione

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Technology Process of 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione

There total 9 articles about 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 183433-89-8
2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester

: 183433-90-1
2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione

Guidance literature:: With trifluoroacetic acid; In toluene; at 75 ℃; for 24h;
DOI:10.1002/jhet.5570400407

Reference yield:

: 100-39-0
benzyl bromide

: 183433-90-1
2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 90 percent / tetrahydrofuran / 8 h / 20 °C

2.1: 89 percent / potassium acetate; palladium acetate; 1,3-bis(diphenylphosphino)propane / dimethylformamide / 25 h / 85 °C / 775.72 Torr

3.1: 97 percent / sodium iodide; trimethylsilyl chloride / acetonitrile / 24 h / 20 °C

4.1: 85 percent / cesium carbonate / dimethylsulfoxide / 3 h / 65 °C

5.1: 73 percent / trifluoroacetic acid / toluene / 24 h / 75 °C

With chloro-trimethyl-silane; 1,3-bis-(diphenylphosphino)propane; potassium acetate; palladium diacetate; sodium hydride; caesium carbonate; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/jhet.5570400407

Reference yield:

: 183433-64-9
6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridine

: 183433-90-1
2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / heptane; hexane / 1.75 h / 0 °C

1.2: 66 percent / heptane; hexane / 2 h / 0 °C

2.1: 99 percent / aq. trifluoroacetic acid / 4 h / 40 °C

3.1: 85 percent / sodium borohydride / aq. methanol / 0.33 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

4.2: 90 percent / tetrahydrofuran / 8 h / 20 °C

5.1: 89 percent / potassium acetate; palladium acetate; 1,3-bis(diphenylphosphino)propane / dimethylformamide / 25 h / 85 °C / 775.72 Torr

6.1: 97 percent / sodium iodide; trimethylsilyl chloride / acetonitrile / 24 h / 20 °C

7.1: 85 percent / cesium carbonate / dimethylsulfoxide / 3 h / 65 °C

8.1: 73 percent / trifluoroacetic acid / toluene / 24 h / 75 °C

With sodium tetrahydroborate; n-butyllithium; chloro-trimethyl-silane; 1,3-bis-(diphenylphosphino)propane; potassium acetate; palladium diacetate; sodium hydride; caesium carbonate; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; methanol; hexane; n-heptane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/jhet.5570400407