2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester
CAS No.:183433-89-8
Molecular Formula:C₂₄H₂₉NO₅
Molecular Weight:411.498
Hs Code.:

Synonyms:2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester

Suppliers and Price of 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester

There total 8 articles about 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 183433-88-7
1,6-dihydro-5-methyl-6-oxo-4-[1-(phenylmethoxy)propyl]-2-pyridinecarboxylic acid, propyl ester

: 183433-89-8
2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 65 ℃; for 3h;
DOI:10.1002/jhet.5570400407

Reference yield:

: 100-39-0
benzyl bromide

: 183433-89-8
2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 90 percent / tetrahydrofuran / 8 h / 20 °C

2.1: 89 percent / potassium acetate; palladium acetate; 1,3-bis(diphenylphosphino)propane / dimethylformamide / 25 h / 85 °C / 775.72 Torr

3.1: 97 percent / sodium iodide; trimethylsilyl chloride / acetonitrile / 24 h / 20 °C

4.1: 85 percent / cesium carbonate / dimethylsulfoxide / 3 h / 65 °C

With chloro-trimethyl-silane; 1,3-bis-(diphenylphosphino)propane; potassium acetate; palladium diacetate; sodium hydride; caesium carbonate; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570400407

Reference yield:

: 183433-64-9
6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridine

: 183433-89-8
2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / heptane; hexane / 1.75 h / 0 °C

1.2: 66 percent / heptane; hexane / 2 h / 0 °C

2.1: 99 percent / aq. trifluoroacetic acid / 4 h / 40 °C

3.1: 85 percent / sodium borohydride / aq. methanol / 0.33 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

4.2: 90 percent / tetrahydrofuran / 8 h / 20 °C

5.1: 89 percent / potassium acetate; palladium acetate; 1,3-bis(diphenylphosphino)propane / dimethylformamide / 25 h / 85 °C / 775.72 Torr

6.1: 97 percent / sodium iodide; trimethylsilyl chloride / acetonitrile / 24 h / 20 °C

7.1: 85 percent / cesium carbonate / dimethylsulfoxide / 3 h / 65 °C

With sodium tetrahydroborate; n-butyllithium; chloro-trimethyl-silane; 1,3-bis-(diphenylphosphino)propane; potassium acetate; palladium diacetate; sodium hydride; caesium carbonate; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; methanol; hexane; n-heptane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570400407