Technology Process of 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester
There total 8 articles about 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
1.2: 90 percent / tetrahydrofuran / 8 h / 20 °C
2.1: 89 percent / potassium acetate; palladium acetate; 1,3-bis(diphenylphosphino)propane / dimethylformamide / 25 h / 85 °C / 775.72 Torr
3.1: 97 percent / sodium iodide; trimethylsilyl chloride / acetonitrile / 24 h / 20 °C
4.1: 85 percent / cesium carbonate / dimethylsulfoxide / 3 h / 65 °C
With
chloro-trimethyl-silane; 1,3-bis-(diphenylphosphino)propane; potassium acetate; palladium diacetate; sodium hydride; caesium carbonate; sodium iodide;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570400407
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-BuLi / heptane; hexane / 1.75 h / 0 °C
1.2: 66 percent / heptane; hexane / 2 h / 0 °C
2.1: 99 percent / aq. trifluoroacetic acid / 4 h / 40 °C
3.1: 85 percent / sodium borohydride / aq. methanol / 0.33 h / 0 °C
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
4.2: 90 percent / tetrahydrofuran / 8 h / 20 °C
5.1: 89 percent / potassium acetate; palladium acetate; 1,3-bis(diphenylphosphino)propane / dimethylformamide / 25 h / 85 °C / 775.72 Torr
6.1: 97 percent / sodium iodide; trimethylsilyl chloride / acetonitrile / 24 h / 20 °C
7.1: 85 percent / cesium carbonate / dimethylsulfoxide / 3 h / 65 °C
With
sodium tetrahydroborate; n-butyllithium; chloro-trimethyl-silane; 1,3-bis-(diphenylphosphino)propane; potassium acetate; palladium diacetate; sodium hydride; caesium carbonate; trifluoroacetic acid; sodium iodide;
In
tetrahydrofuran; methanol; hexane; n-heptane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570400407
