4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid

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Chemical Name:4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid
CAS No.:1072915-73-1
Molecular Formula:C₁₈H₁₃Cl₂F₃N₂O₄
Molecular Weight:449.213
Hs Code.:

Synonyms:4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid

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Chemical Property of 4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid

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Technology Process of 4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid

There total 4 articles about 4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072915-72-0
methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate

: 1072915-73-1
4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid

Guidance literature:: methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate; With sodium hydroxide; water; In 1,4-dioxane; at 80 ℃;

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1072915-73-1
4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Heating / reflux

2.2: 2 h / 60 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C

4.1: sodium hydroxide; water / 1,4-dioxane / 80 °C

4.2: 20 °C

With sodium hydroxide; carbonochloridic acid 1-chloro-ethyl ester; water; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1025025-19-7
rac-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

: 1072915-73-1
4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C

2.1: sodium hydroxide; water / 1,4-dioxane / 80 °C

2.2: 20 °C

With sodium hydroxide; water; potassium carbonate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one;