methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate

Base Information

• Chemical Name: methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate
• CAS No.: 1072915-72-0
• Molecular Formula: C₁₉H₁₅Cl₂F₃N₂O₄
• Molecular Weight: 463.24
• Mol file: 1072915-72-0.mol

Synonyms:methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate

Chemical Property of methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate

There total 3 articles about methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (1025025-19-7) + methyl 4-fluoro-2-nitrobenzoate (151504-81-3) → methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate (1072915-72-0)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 2h;

Reference yield:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4) → methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate (1072915-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Heating / reflux

2.2: 2 h / 60 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C

With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

1-benzyl-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (1025025-18-6) → methyl 4-[3-(3,5-dichlorophenyl)-3-(trifluorornethyl)pyrrolidin-1-yl]-2-nitrobenzoate (1072915-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Heating / reflux

1.2: 2 h / 60 °C

2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C

With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; In 1-methyl-pyrrolidin-2-one; 1,2-dichloro-ethane;

upstream raw materials:

rac-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

methyl 4-fluoro-2-nitrobenzoate

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

1-benzyl-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

Downstream raw materials:

4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitrobenzoic acid

4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-nitro-N-(pyridin-2-ylmethyl)benzamide