N-(2-Benzoylphenyl)acetamide

Base Information

• Chemical Name: N-(2-Benzoylphenyl)acetamide
• CAS No.: 85-99-4
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Hs Code.: 2924299090
• NSC Number: 126369
• DSSTox Substance ID: DTXSID10234051
• Nikkaji Number: J79.434A
• Wikidata: Q83115762
• Mol file: 85-99-4.mol

Synonyms:2-Acetamidobenzophenone;N-(2-Benzoylphenyl)acetamide;85-99-4;2'-Benzoylacetanilide;Acetamide, N-(2-benzoylphenyl)-;Acetamido-2 benzophenone [French];Acetamido-2 benzophenone;2-Acetaminobenzophenone;NSC126369;acetylaminobenzophenone;Acetanilide, 2'-benzoyl-;2-(Acetylamino)benzophenone;N-acetyl 2-amino benzophenone;SCHEMBL2047090;DTXSID10234051;AMY25111;MFCD00442710;AKOS002789224;LS-8214;NSC 126369;NSC-126369;FT-0611293;A841524;AG-670/31976035;J-800237

Chemical Property of N-(2-Benzoylphenyl)acetamide

Chemical Property:

• Appearance/Colour: light yellow powder
• Melting Point: 87 °C
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 477 °C at 760 mmHg
• PKA: 14.54±0.70(Predicted)
• Flash Point: 196.2 °C
• PSA: 46.17000
• Density: 1.192 g/cm³
• LogP: 2.94900
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 239.094628657
• Heavy Atom Count: 18
• Complexity: 308

Purity/Quality:

98%min ^*data from raw suppliers

2-Benzoylacetanilide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=CC=C1C(=O)C2=CC=CC=C2

Technology Process of N-(2-Benzoylphenyl)acetamide

There total 31 articles about N-(2-Benzoylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic anhydride (108-24-7) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 2-acetamidobenzophenone (85-99-4)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1039/C6CC08788D

Reference yield: 96.0%

2-methyl-3-phenyl-1H-indole (4757-69-1) → 4-phenyl-2-quinolinone (5855-57-2) + 2-acetamidobenzophenone (85-99-4)

Guidance literature:

With potassium nitrite; 18-crown-6 ether; In tetrahydrofuran; at 25 ℃; for 15h; Mechanism; Product distribution; under argon or oxygen;

DOI:10.1016/S0040-4039(00)85631-2

Reference yield: 95.0%

sodium acetate (127-09-3) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 2-acetamidobenzophenone (85-99-4)

Guidance literature:

With acetic anhydride; at 80 ℃; for 1h;

DOI:10.1016/j.ejmech.2017.05.002

upstream raw materials:

2-methyl-4-oxo-3,1-benzoxazine

diethyl ether

benzene

2-methyl-3-phenyl-1H-indole

Downstream raw materials:

2-methyl-4-phenylquinazoline

4-phenyl-quinolin-2-ol

acetic acid-(2-benzoyl-N-chloro-anilide)

(2-aminophenyl)(phenyl)methanone

Refernces

• 1、 Mirzaei, Salimeh,Hadizadeh, Farzin,Eisvand, Farhad,Mosaffa, Fatemeh,Ghodsi, Razieh. "Synthesis, structure-activity relationship and molecular docking studies of novel quinoline-chalcone hybrids as potential anticancer agents and tubulin inhibitors". . . Retrieved 2019/11/26.
• 2、 Wei, Wen-Tao,Sheng, Jian-Fei,Miao, Hui,Luo, Xiang,Song, Xian-Heng,Yan, Ming,Zou, Yong. "Transition-Metal-Free Synthesis of Acridones via Base-Mediated Intramolecular Oxidative C?H Amination". supporting information. p. 2101 - 2106. Retrieved 2018/06/14.