C₁₉H₁₉NO₄

Base Information

• Chemical Name: C₁₉H₁₉NO₄
• CAS No.: 123806-61-1
• Molecular Formula: C₁₉H₁₉NO₄
• Molecular Weight: 325.364
• Mol file: 123806-61-1.mol

Synonyms:C₁₉H₁₉NO₄

Chemical Property of C₁₉H₁₉NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₉NO₄

There total 6 articles about C₁₉H₁₉NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + (1R,2S)-1-Benzyloxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid (86087-20-9) → C19H19NO4 (123806-61-1)

Guidance literature:

With sulfuric acid; at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2012.11.046

Reference yield:

N-(benzyloxycarbonyl)-L-serine p-nitrobenzyl ester (6169-33-1) → C19H19NO4 (123806-61-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dicyclohexyl-carbodiimide; copper dichloride / dichloromethane / 19 h / 20 °C

2.1: dichloromethane; diethyl ether / 0 - 20 °C

3.1: sodium hydroxide / 1,4-dioxane; water / 4 h / 20 °C

4.1: brucine / water; ethanol / 20 °C

4.2: Dowex 50w

5.1: sulfuric acid / 48 h / 20 °C

With sulfuric acid; dicyclohexyl-carbodiimide; brucine; sodium hydroxide; copper dichloride; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.11.046

Reference yield:

N-(benzyloxycarbonyl)dehydroalanine p-nitrobenzyl ester (52715-73-8) → C19H19NO4 (123806-61-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dichloromethane; diethyl ether / 0 - 20 °C

2.1: sodium hydroxide / 1,4-dioxane; water / 4 h / 20 °C

3.1: brucine / water; ethanol / 20 °C

3.2: Dowex 50w

4.1: sulfuric acid / 48 h / 20 °C

With sulfuric acid; brucine; sodium hydroxide; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.11.046

upstream raw materials:

Cyclopropyl-Z-phenylalanine methyl ester hydrochloride

benzyl chloroformate

N-(benzyloxycarbonyl)-L-serine p-nitrobenzyl ester

N-(benzyloxycarbonyl)dehydroalanine p-nitrobenzyl ester

Downstream raw materials:

N-(benzyloxycarbonyl)-(2RS)-cyclopropyl-Z-phenylalanine

methyl (1R,2S)-1-amino-2-phenylcyclopropanecarboxylate

C₂₃H₃₃N₃O₅S

Refernces

• 1、 Kimura, Hitoshi,Stammer, Charles H.. "Resolution and Deblocking of Racemic N-(Benzyloxycarbonyl)cyclopropylphenylalanine". . p. 2440 - 2441. Retrieved 2007/10/02.