ethyl (7S,8R)-8-{[(benzyloxy)carbonyl]amino}-1,4-dioxaspiro[4.5]decane-7-carboxylate

Base Information

Chemical Name:ethyl (7S,8R)-8-{[(benzyloxy)carbonyl]amino}-1,4-dioxaspiro[4.5]decane-7-carboxylate
CAS No.:1092728-40-9
Molecular Formula:C₁₉H₂₅NO₆
Molecular Weight:363.411
Hs Code.:

Synonyms:ethyl (7S,8R)-8-{[(benzyloxy)carbonyl]amino}-1,4-dioxaspiro[4.5]decane-7-carboxylate

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Chemical Property of ethyl (7S,8R)-8-{[(benzyloxy)carbonyl]amino}-1,4-dioxaspiro[4.5]decane-7-carboxylate

Chemical Property:

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Technology Process of ethyl (7S,8R)-8-{[(benzyloxy)carbonyl]amino}-1,4-dioxaspiro[4.5]decane-7-carboxylate

There total 4 articles about ethyl (7S,8R)-8-{[(benzyloxy)carbonyl]amino}-1,4-dioxaspiro[4.5]decane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092728-39-6
ethyl (7S,8R)-8-amino-1,4-dioxaspiro[4.5]decane-7-carboxylate hydrobromide

: 501-53-1,94274-21-2
benzyl chloroformate

: 1092728-40-9
ethyl (7S,8R)-8-{[(benzyloxy)carbonyl]amino}-1,4-dioxaspiro[4.5]decane-7-carboxylate

Guidance literature:: With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; Cooling with ice;

Reference yield:

: 1092728-38-5
ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide

: 1092728-40-9
ethyl (7S,8R)-8-{[(benzyloxy)carbonyl]amino}-1,4-dioxaspiro[4.5]decane-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere

2: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice

With hydrogen; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water;

Reference yield:

: 813445-18-0
ethyl (R)-8-((1-phenylethyl)amino)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 1092728-40-9
ethyl (7S,8R)-8-{[(benzyloxy)carbonyl]amino}-1,4-dioxaspiro[4.5]decane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C

1.2: 2 h / 0 - 10 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere

3.1: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice

With sodium tetrahydroborate; hydrogen; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; isobutyric Acid;