(S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one

Base Information

Chemical Name:(S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one
CAS No.:312326-49-1
Molecular Formula:C₂₇H₃₃NO₇
Molecular Weight:483.562
Hs Code.:

Synonyms:(S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one

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Chemical Property of (S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one

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Technology Process of (S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one

There total 5 articles about (S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 131685-53-5,101711-78-8
(S)-4-benzyl-3-propionyl-2-oxazolidinone

: 312326-48-0
[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-acetaldehyde

: 312326-49-1
(S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one

Guidance literature:: (S)-4-benzyl-3-propionyl-2-oxazolidinone; With di-n-butylboryl trifluoromethanesulfonate; In dichloromethane;

[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-acetaldehyde;
DOI:10.1016/S0040-4039(00)01337-X

Reference yield:

: 5694-95-1
2-(2-(2-hydroxyethyl)-1,3-dioxolan-2-yl)ethanol

: 312326-49-1
(S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran

1.2: 76 percent / Bu₄NI

2.1: 97 percent / Dess-Martin periodinane

3.1: 83 percent / Bu₂BOTf / CH₂Cl₂

With di-n-butylboryl trifluoromethanesulfonate; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 1.1: Metallation / 2.1: Oxidation / 3.1: Metallation;
DOI:10.1016/S0040-4039(00)01337-X

Reference yield:

: 6506-31-6
dimethyl acetonedicarboxylate ethylene ketal

: 312326-49-1
(S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / LiAlH₄ / tetrahydrofuran

2.1: NaH / tetrahydrofuran

2.2: 76 percent / Bu₄NI

3.1: 97 percent / Dess-Martin periodinane

4.1: 83 percent / Bu₂BOTf / CH₂Cl₂

With lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 1.1: Reduction / 2.1: Metallation / 3.1: Oxidation / 4.1: Metallation;
DOI:10.1016/S0040-4039(00)01337-X