C₂₈H₄₃NO₅Si

Base Information

• Chemical Name: C₂₈H₄₃NO₅Si
• CAS No.: 1429412-50-9
• Molecular Formula: C₂₈H₄₃NO₅Si
• Molecular Weight: 501.739
• Mol file: 1429412-50-9.mol

Synonyms:C₂₈H₄₃NO₅Si

Chemical Property of C₂₈H₄₃NO₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₄₃NO₅Si

There total 11 articles about C₂₈H₄₃NO₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C26H36O4Si (1429412-40-7) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → C28H43NO5Si (1429412-50-9)

Guidance literature:

N,O-dimethylhydroxylamine*hydrochloride; With trimethylaluminum; In dichloromethane; toluene; at 0 ℃; for 0.333333h;

C₂₆H₃₆O₄Si; In dichloromethane; toluene; at 0 ℃; for 0.5h;

With hydrogenchloride; In dichloromethane; water; toluene;

DOI:10.1039/c3ob27508f

Reference yield:

3-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylpropan-1-ol (147509-22-6) → C28H43NO5Si (1429412-50-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 6 h / Reflux

2.1: (R)-Tol-BINAP; tetrabutylammonium triphenyldifluorosilicate; copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran / 16 h / -78 °C

3.1: methanol; toluene / 1 h / 110 °C / Sealed tube

4.1: potassium carbonate / acetone / 5 h

5.1: hydrogen / isopropyl alcohol / 6 h / 20 °C

6.1: trimethylaluminum / toluene; dichloromethane / 0.33 h / 0 °C

6.2: 0.5 h / 0 °C

With (R)-Tol-BINAP; hydrogen; trimethylaluminum; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; tetrabutylammonium triphenyldifluorosilicate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; isopropyl alcohol; acetone; toluene; 2.1: |Mukaiyama Aldol Addition;

DOI:10.1039/c3ob27508f

Reference yield:

2,2-Dimethyl-1,3-propanediol (126-30-7) → C28H43NO5Si (1429412-50-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydride / nujol; tetrahydrofuran / 16.5 h / 0 °C

1.2: 3.3 h / 0 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 6 h / Reflux

3.1: (R)-Tol-BINAP; tetrabutylammonium triphenyldifluorosilicate; copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran / 16 h / -78 °C

4.1: methanol; toluene / 1 h / 110 °C / Sealed tube

5.1: potassium carbonate / acetone / 5 h

6.1: hydrogen / isopropyl alcohol / 6 h / 20 °C

7.1: trimethylaluminum / toluene; dichloromethane / 0.33 h / 0 °C

7.2: 0.5 h / 0 °C

With (R)-Tol-BINAP; hydrogen; trimethylaluminum; copper(II) bis(trifluoromethanesulfonate); sodium hydride; potassium carbonate; tetrabutylammonium triphenyldifluorosilicate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; nujol; dichloromethane; ethyl acetate; isopropyl alcohol; acetone; toluene; 3.1: |Mukaiyama Aldol Addition;

DOI:10.1039/c3ob27508f

upstream raw materials:

C₂₈H₃₈O₅Si

C₂₆H₃₆O₅Si

C₂₅H₃₂O₄Si

2,2-Dimethyl-1,3-propanediol

Downstream raw materials:

C₄₅H₆₆O₅Si₂

C₃₄H₅₇NO₅Si₂