2-((S)-4-(benzyloxy)-3-methylbutyl)-2-((S)-hex-5-en-2-yl)-1,3-dioxalane

Base Information

Chemical Name:2-((S)-4-(benzyloxy)-3-methylbutyl)-2-((S)-hex-5-en-2-yl)-1,3-dioxalane
CAS No.:1408299-06-8
Molecular Formula:C₂₁H₃₂O₃
Molecular Weight:332.483
Hs Code.:

Synonyms:2-((S)-4-(benzyloxy)-3-methylbutyl)-2-((S)-hex-5-en-2-yl)-1,3-dioxalane

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Chemical Property of 2-((S)-4-(benzyloxy)-3-methylbutyl)-2-((S)-hex-5-en-2-yl)-1,3-dioxalane

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Technology Process of 2-((S)-4-(benzyloxy)-3-methylbutyl)-2-((S)-hex-5-en-2-yl)-1,3-dioxalane

There total 9 articles about 2-((S)-4-(benzyloxy)-3-methylbutyl)-2-((S)-hex-5-en-2-yl)-1,3-dioxalane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1408299-05-7
(2S,6S)-1-(benzyloxy)-2,6-dimethyldec-9-en-5-one

: 107-21-1
ethylene glycol

: 1408299-06-8
2-((S)-4-(benzyloxy)-3-methylbutyl)-2-((S)-hex-5-en-2-yl)-1,3-dioxalane

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 4h; Reflux;
DOI:10.1016/j.tetasy.2012.07.006

Reference yield:

: 887706-39-0
(S)-5-(benzyloxy)-4-methylpentan-1-ol

: 1408299-06-8
2-((S)-4-(benzyloxy)-3-methylbutyl)-2-((S)-hex-5-en-2-yl)-1,3-dioxalane

Guidance literature:: Multi-step reaction with 7 steps

1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C

2.2: 0.5 h / 0 °C

2.3: 1 h / 0 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

4.1: dmap; triethylamine / dichloromethane / 20 h / 0 - 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Reflux

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

7.1: toluene-4-sulfonic acid / benzene / 4 h / Reflux

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; benzene; 2.1: |Evans Aldol Reaction / 2.2: |Evans Aldol Reaction;
DOI:10.1016/j.tetasy.2012.07.006

Reference yield:

: 134916-00-0
(4S)-4-benzyl-3-(hex-5-enoyl)-1,3-oxazolidin-2-one

: 1408299-06-8
2-((S)-4-(benzyloxy)-3-methylbutyl)-2-((S)-hex-5-en-2-yl)-1,3-dioxalane

Guidance literature:: Multi-step reaction with 6 steps

1.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C

1.2: 0.5 h / 0 °C

1.3: 1 h / 0 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

3.1: dmap; triethylamine / dichloromethane / 20 h / 0 - 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Reflux

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

6.1: toluene-4-sulfonic acid / benzene / 4 h / Reflux

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; toluene-4-sulfonic acid; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; benzene; 1.1: |Evans Aldol Reaction / 1.2: |Evans Aldol Reaction;
DOI:10.1016/j.tetasy.2012.07.006