Technology Process of 9-ethyl-6,8-dimethyl-2-(phenylethynyl)-9H-carbazole-3-carbaldehyde
There total 6 articles about 9-ethyl-6,8-dimethyl-2-(phenylethynyl)-9H-carbazole-3-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-bromo-9-ethyl-6-methyl-9H-carbazole-3-carbaldehyde; phenylacetylene;
With
triethylamine;
In
tetrahydrofuran;
at 20 ℃;
Molecular sieve;
Inert atmosphere;
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
In
tetrahydrofuran;
Molecular sieve;
Inert atmosphere;
Heating;
DOI:10.1039/c1ob05258f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethyl phosphite / 5 h / Reflux
2.1: potassium hydroxide / acetone / 0.5 h / Reflux
2.2: 1 h / Reflux
3.1: trichlorophosphate / 0 - 70 °C
4.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 3 h / 200 °C
5.1: trichlorophosphate / N,N-dimethyl-formamide / 0 - 70 °C
6.1: triethylamine / tetrahydrofuran / 20 °C / Molecular sieve; Inert atmosphere
6.2: Molecular sieve; Inert atmosphere; Heating
With
hydrazine hydrate; triethylamine; potassium hydroxide; triethyl phosphite; trichlorophosphate;
In
tetrahydrofuran; ethylene glycol; N,N-dimethyl-formamide; acetone;
3.1: Vilsmeier formylation / 4.1: Wolff-Kishner reduction / 5.1: Vilsmeier formylation / 6.1: Sonogashira coupling / 6.2: Sonogashira coupling;
DOI:10.1039/c1ob05258f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydroxide / acetone / 0.5 h / Reflux
1.2: 1 h / Reflux
2.1: trichlorophosphate / 0 - 70 °C
3.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 3 h / 200 °C
4.1: trichlorophosphate / N,N-dimethyl-formamide / 0 - 70 °C
5.1: triethylamine / tetrahydrofuran / 20 °C / Molecular sieve; Inert atmosphere
5.2: Molecular sieve; Inert atmosphere; Heating
With
hydrazine hydrate; triethylamine; potassium hydroxide; trichlorophosphate;
In
tetrahydrofuran; ethylene glycol; N,N-dimethyl-formamide; acetone;
2.1: Vilsmeier formylation / 3.1: Wolff-Kishner reduction / 4.1: Vilsmeier formylation / 5.1: Sonogashira coupling / 5.2: Sonogashira coupling;
DOI:10.1039/c1ob05258f
