2-Amino-5-(diaminomethylideneazaniumyl)pentanoate

Base Information

• Chemical Name: 2-Amino-5-(diaminomethylideneazaniumyl)pentanoate
• CAS No.: 7200-25-1
• Molecular Formula: C6H14N4O2
• Molecular Weight: 174.203
• Hs Code.: 29252000
• Mol file: 7200-25-1.mol

Synonyms:2-amino-5-(diaminomethylideneazaniumyl)pentanoate

Chemical Property of 2-Amino-5-(diaminomethylideneazaniumyl)pentanoate

Chemical Property:

• Appearance/Colour: White powder
• Melting Point: 228-233 °C (dec.)
• Refractive Index: 1.6700 (estimate)
• Boiling Point: 367.56 °C at 760 mmHg
• PKA: 2.49±0.24(Predicted)
• Flash Point: 176.094 °C
• PSA: 125.22000
• Density: 1.467 g/cm³
• LogP: 0.55280
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: 155 g/L (20 ºC)
• XLogP3: -3.5
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 174.11167570
• Heavy Atom Count: 12
• Complexity: 171

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

DL-Arginine ≥97.0% (NT) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(C(=O)[O-])N)C[NH+]=C(N)N
• Uses: DL-Arginine is used in the synthesis of creatine and polyamines. DL-Arg is used in physicochemical analysis of amino acid complexation dynamics and crystal structure formations.

Technology Process of 2-Amino-5-(diaminomethylideneazaniumyl)pentanoate

There total 34 articles about 2-Amino-5-(diaminomethylideneazaniumyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-amino-5-guanidino-pentanoic acid 9-bora-bicyclo[3.3.1]non-9-yl ester → Arg (7200-25-1,25212-18-4)

Guidance literature:

2-amino-5-guanidino-pentanoic acid 9-bora-bicyclo[3.3.1]non-9-yl ester; With hydrogenchloride; In methanol; at 20 ℃; for 0.166667h;

With methyloxirane; In methanol; water; Further stages.;

DOI:10.1021/ol017241b

Reference yield: 55.0%

2-[2-Benzoylamino-1-methoxy-eth-(Z)-ylideneamino]-5-guanidino-pentanoic acid → Arg (7200-25-1,25212-18-4) + methyl hippurate (1205-08-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; Yields of byproduct given;

DOI:10.1016/0040-4039(96)01716-9

Reference yield:

2-Benzyloxycarbonylamino-5-guanidino-pentanoic acid (1234-35-1,5619-02-3,6382-93-0) → L-arginine (74-79-3,157-06-2,7004-12-8,7200-25-1,25212-18-4) + benzyl alcohol (100-51-6,185532-71-2)

Guidance literature:

With N^α-benzyloxycarbonyl amino acid urethane hydrolase II; cobalt(II); at 33 ℃; for 0.5h; Rate constant; pH=6.5;

upstream raw materials:

L-arginine

N-α-benzoyl-DL-arginine

O-methylisourea p-toluenesulfonate

DL-ornithine hydrochloride

Downstream raw materials:

D-ornithine

L-arginine

urea

D-arginine

Refernces

• 1、 Dzierzbicka, Krystyna,Wardowska, Anna,Rogalska, Ma?gorzata,Trzonkowski, Piotr. "New conjugates of muramyl dipeptide and nor-muramyl dipeptide linked to tuftsin and retro-tuftsin derivatives significantly influence their biological activity". body text. p. 217 - 223. Retrieved 2012/08/29.
• 2、 -. "Synthetic Peptide Copolymers for Treatment and Prevention of Cardiovascular Disorders". . . Retrieved 2009/05/28.