O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite

Base Information

• Chemical Name: O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite
• CAS No.: 171081-12-2
• Molecular Formula: C₃₄H₃₅FN₃O₈P
• Molecular Weight: 663.639

Synonyms:O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite

Chemical Property of O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite

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Technology Process of O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite

There total 2 articles about O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Hydroxypropionitrile (109-78-4) + 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite (162611-40-7,162611-41-8,171081-08-6) → O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite (171081-12-2)

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 0.166667h; Ambient temperature;

DOI:10.1246/cl.1995.727

Reference yield: 99.0%

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + O-(2-cyanoethyl) N,N-diisopropylfluorophosphoramidite (191151-90-3) → O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite (171081-12-2)

Guidance literature:

With chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1039/b103082p

Reference yield: 98.0%

O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite (171081-12-2) → O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate (171081-16-6)

Guidance literature:

With tert.-butylhydroperoxide; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1039/b103082p

upstream raw materials:

3-Hydroxypropionitrile

5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite

5'-O-(4-4'-dimethoxytrityl)thymidine

O-(2-cyanoethyl) N,N-diisopropylfluorophosphoramidite

Downstream raw materials:

O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate

O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) thiophosphorofluoridate

O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen thiophosphorofluoridate

O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen phosphorofluoridate

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