n-(2-Hydroxyethyl)-n,4-dimethylbenzenesulfonamide

Base Information

Chemical Name:n-(2-Hydroxyethyl)-n,4-dimethylbenzenesulfonamide
CAS No.:59724-61-7
Molecular Formula:C10H15 N O3 S
Molecular Weight:229.3
Hs Code.:
NSC Number:30139
DSSTox Substance ID:DTXSID10283160
Wikidata:Q82017630
Mol file:59724-61-7.mol

Synonyms:n-(2-hydroxyethyl)-n,4-dimethylbenzenesulfonamide;59724-61-7;NSC 30139;NSC30139;SCHEMBL7200356;DTXSID10283160;NSC-30139;AKOS010186881;FT-0669622

Suppliers and Price of n-(2-Hydroxyethyl)-n,4-dimethylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-2-Hydroxyethyl-N-methyl-p-toluenesulfonamide
1g
$ 165.00

Medical Isotopes, Inc.
N-2-Hydroxyethyl-N-methyl-p-toluenesulfonamide
1 g
$ 650.00

Total 5 raw suppliers

Chemical Property of n-(2-Hydroxyethyl)-n,4-dimethylbenzenesulfonamide

Chemical Property:

Vapor Pressure:2.32E-06mmHg at 25°C
Boiling Point:377.2°Cat760mmHg
PKA:14.29±0.10(Predicted)
Flash Point:181.9°C
PSA：65.99000
Density:1.237g/cm³
LogP:1.68860
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:229.07726451
Heavy Atom Count:15
Complexity:276

Purity/Quality:

99% ^*data from raw suppliers

N-2-Hydroxyethyl-N-methyl-p-toluenesulfonamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)N(C)CCO
Uses N-2-Hydroxyethyl-N-methyl- N-2-Hydroxyethyl-N-methyl-p-toluenesulfonamide, is used for the preparation of Rosiglitazone (R693500) derivatives, acting as antidiabetic agents.

Technology Process of n-(2-Hydroxyethyl)-n,4-dimethylbenzenesulfonamide

There total 5 articles about n-(2-Hydroxyethyl)-n,4-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 98-59-9
p-toluenesulfonyl chloride

: 59724-61-7
N-(2-hydroxyethyl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 5 ℃; for 4h;
DOI:10.1248/cpb.42.1459

Reference yield: 90.0%

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 824-79-3
sodium 4-methylbenzenesulfinate

: 59724-61-7
N-(2-hydroxyethyl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; acetonitrile; at 50 ℃; for 8h;
DOI:10.1039/c4ra13454k