6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Base Information

Chemical Name:6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide
CAS No.:1423008-02-9
Molecular Formula:C₂₇H₂₄BrFN₂O₅S
Molecular Weight:587.466
Hs Code.:

Synonyms:6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

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Chemical Property of 6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

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Technology Process of 6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

There total 15 articles about 6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1423008-01-8
methyl 2-bromo-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

: 1423008-02-9
6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: With methanol; lithium borohydride; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1423007-83-3
methyl 5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-nitrobenzoate

: 1423008-02-9
6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 775.74 Torr

2.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C

2.2: 0 - 55 °C

3.1: methanol; lithium borohydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With methanol; lithium borohydride; palladium 10% on activated carbon; hydrogen bromide; hydrogen; sodium nitrite; In tetrahydrofuran; methanol; water; acetonitrile; 2.1: |Sandmeyer Reaction;

Reference yield:

: 1423007-84-4
methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

: 1423008-02-9
6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C

1.2: 0 - 55 °C

2.1: methanol; lithium borohydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With methanol; lithium borohydride; hydrogen bromide; sodium nitrite; In tetrahydrofuran; water; acetonitrile; 1.1: |Sandmeyer Reaction;