(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid

Base Information

Chemical Name:(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid
CAS No.:1423008-05-2
Molecular Formula:C₂₉H₃₀BFN₂O₈S
Molecular Weight:596.441
Hs Code.:

(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid

Synonyms:(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid

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Chemical Property of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid

Chemical Property:

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Technology Process of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid

There total 18 articles about (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1423008-04-1
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(3-((methoxymethoxy)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

: 1423008-05-2
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid

Guidance literature:: With hydrogenchloride; sodium periodate; In methanol; water; at 20 ℃;

Reference yield:

: 1423007-84-4
methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

: 1423008-05-2
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C

1.2: 0 - 55 °C

2.1: methanol; lithium borohydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 50 °C / Inert atmosphere

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere; Sealed tube

5.1: hydrogenchloride; sodium periodate / water; methanol / 20 °C

With hydrogenchloride; methanol; sodium periodate; lithium borohydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen bromide; potassium acetate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile; 1.1: |Sandmeyer Reaction;

Reference yield:

: 1423008-02-9
6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

: 1423008-05-2
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 50 °C / Inert atmosphere

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride; sodium periodate / water; methanol / 20 °C

With hydrogenchloride; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water;