5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide
CAS No.:1423008-00-7
Molecular Formula:C₂₇H₂₄BFN₂O₆S
Molecular Weight:534.373
Hs Code.:

Synonyms:5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

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Technology Process of 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

There total 19 articles about 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1423008-05-2
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-[(methoxymethoxy)methyl]phenyl)boronic acid

: 1423008-00-7
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; water; at 70 ℃; Inert atmosphere;

Reference yield:

: 1423007-84-4
methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

: 1423008-00-7
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C

1.2: 0 - 55 °C

2.1: methanol; lithium borohydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 50 °C / Inert atmosphere

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere; Sealed tube

5.1: hydrogenchloride; sodium periodate / water; methanol / 20 °C

6.1: hydrogenchloride / water; tetrahydrofuran; methanol / 70 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium periodate; lithium borohydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen bromide; potassium acetate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile; 1.1: |Sandmeyer Reaction;

Reference yield:

: 1423008-02-9
6-{N-[4-bromo-3-(hydroxymethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

: 1423008-00-7
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 50 °C / Inert atmosphere

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride; sodium periodate / water; methanol / 20 °C

4: hydrogenchloride / water; tetrahydrofuran; methanol / 70 °C / Inert atmosphere

With hydrogenchloride; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water;