10a-(4-fluorophenyl)-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one

Base Information

Chemical Name:10a-(4-fluorophenyl)-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one
CAS No.:1379605-80-7
Molecular Formula:C₁₆H₁₄FN₃O
Molecular Weight:283.305
Hs Code.:

Synonyms:10a-(4-fluorophenyl)-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one

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Chemical Property of 10a-(4-fluorophenyl)-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one

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Technology Process of 10a-(4-fluorophenyl)-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one

There total 3 articles about 10a-(4-fluorophenyl)-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1379605-79-4
3-[2-(4-fluorophenyl)-2-oxoethyl]pyridine-2-carboxylic acid

: 107-15-3,85404-18-8
ethylenediamine

: 1379605-80-7
10a-(4-fluorophenyl)-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one

Guidance literature:: In 1,2-dichloro-ethane; for 1h; Reflux;

Reference yield:

: 403-33-8
methyl 4-flurobenzoate

: 1379605-80-7
10a-(4-fluorophenyl)-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 - -5 °C / Inert atmosphere

1.2: 4 h / -78 - 0 °C

1.3: pH 2

2.1: 1,2-dichloro-ethane / 1 h / Reflux

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; 1,2-dichloro-ethane;

Reference yield:

: 4021-07-2
3-methyl-pyridine-2-carboxylic acid

: 1379605-80-7
10a-(4-fluorophenyl)-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 - -5 °C / Inert atmosphere

1.2: 4 h / -78 - 0 °C

1.3: pH 2

2.1: 1,2-dichloro-ethane / 1 h / Reflux

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; 1,2-dichloro-ethane;