(S)-2-({2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid benzyl ester

Base Information

Chemical Name:(S)-2-({2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid benzyl ester
CAS No.:174311-12-7
Molecular Formula:C₂₃H₃₅N₃O₆
Molecular Weight:449.547
Hs Code.:

Synonyms:(S)-2-({2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid benzyl ester

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Chemical Property of (S)-2-({2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid benzyl ester

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Technology Process of (S)-2-({2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid benzyl ester

There total 5 articles about (S)-2-({2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 133498-97-2
t-BuOCO-Gly-Sar-OH

: 89536-89-0
benzyl (2S)-3-methyl-2-(methylamino)butanoate hydrochloride

: 174311-12-7
(S)-2-({2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid benzyl ester

Guidance literature:: With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 24h;
DOI:10.1021/ja952799y

Reference yield:

: 4530-20-5
BOC-glycine

: 174311-12-7
(S)-2-({2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Et₃N, DCC, DMAP / CH₂Cl₂ / 20 h / 25 °C

2: 100 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 3 h / 25 °C

3: 85 percent / Et₃N, DMAP, DCC / CH₂Cl₂ / 24 h / 25 °C

With dmap; lithium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ja952799y

Reference yield:

: 66447-55-0
((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester

: 174311-12-7
(S)-2-({2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-acetyl}-methyl-amino)-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaH / tetrahydrofuran; dimethylformamide / 24 h / Heating

2: HCl / ethyl acetate

3: 85 percent / Et₃N, DMAP, DCC / CH₂Cl₂ / 24 h / 25 °C

With hydrogenchloride; dmap; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja952799y