methyl 6-<(tert-butyldiphenylsilyl)oxy>-2-(methoxycarbonyl)-2-hexenoate

Base Information

• Chemical Name: methyl 6-<(tert-butyldiphenylsilyl)oxy>-2-(methoxycarbonyl)-2-hexenoate
• CAS No.: 149743-12-4
• Molecular Formula: C₂₅H₃₂O₅Si
• Molecular Weight: 440.612
• Mol file: 149743-12-4.mol

Synonyms:methyl 6-<(tert-butyldiphenylsilyl)oxy>-2-(methoxycarbonyl)-2-hexenoate

Chemical Property of methyl 6-<(tert-butyldiphenylsilyl)oxy>-2-(methoxycarbonyl)-2-hexenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-<(tert-butyldiphenylsilyl)oxy>-2-(methoxycarbonyl)-2-hexenoate

There total 1 articles about methyl 6-<(tert-butyldiphenylsilyl)oxy>-2-(methoxycarbonyl)-2-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-((tert-butyldiphenylsilyl)oxy)butanal (127793-62-8) + malonic acid dimethyl ester (108-59-8) → methyl 6-<(tert-butyldiphenylsilyl)oxy>-2-(methoxycarbonyl)-2-hexenoate (149743-12-4)

Guidance literature:

With piperidine; benzoic acid; In benzene; for 4h; Heating;

DOI:10.1021/jo00068a058

Reference yield: 74.0%

methyl 6-<(tert-butyldiphenylsilyl)oxy>-2-(methoxycarbonyl)-2-hexenoate (149743-12-4) + N-(2,2-dimethoxyethyl)-4-(fluorophenyl)carboxamidine (149742-96-1) → 4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(2,2-dimethoxy-ethyl)-2-(4-fluoro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid methyl ester

Guidance literature:

In methanol; at 110 ℃; for 3h;

DOI:10.1021/jo00068a058

Reference yield:

methyl 6-<(tert-butyldiphenylsilyl)oxy>-2-(methoxycarbonyl)-2-hexenoate (149743-12-4) → 4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(2,2-dimethoxy-ethyl)-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / methanol / 3 h / 110 °C

2: 70 percent / N-bromosuccinimide, benzoyl peroxide, potassium carbonate / CCl₄ / 0.5 h / Heating

With N-Bromosuccinimide; Perbenzoic acid; potassium carbonate; In methanol; tetrachloromethane;

DOI:10.1021/jo00068a058

upstream raw materials:

4-((tert-butyldiphenylsilyl)oxy)butanal

malonic acid dimethyl ester