N²-<(S)-N²-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide

Base Information

• Chemical Name: N²-<(S)-N²-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide
• CAS No.: 81838-43-9
• Molecular Formula: C₂₈H₃₁N₃O₃
• Molecular Weight: 457.572
• Mol file: 81838-43-9.mol

Synonyms:N²-<(S)-N²-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide

Chemical Property of N²-<(S)-N²-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N²-<(S)-N²-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide

There total 2 articles about N²-<(S)-N²-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phenylacetyl-3-phenyl-alanine (54582-05-7) → N2-<(S)-N2-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide (81838-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / CH₂Cl₂ / 0.5 h / Ambient temperature

2: CH₂Cl₂ / 12 h / Ambient temperature

With dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/hlca.19920750522

Reference yield:

2,4-dibenzyl-4H-oxazol-5-one (81838-42-8) + L-phenylalanine dimethylamide (29618-17-5) → N2-<(R)-N2-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide (81837-87-8) + N2-<(S)-N2-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide (81838-43-9)

Guidance literature:

In dichloromethane; for 12h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1002/hlca.19920750522

Reference yield: 78.0%

N2-<(S)-N2-(phenylacetyl)phenylalanyl>-L-phenylalanine dimethylamide (81838-43-9) → (S)-3-phenyl-2-phenylacetylamino-propionic acid (738-75-0)

Guidance literature:

With hydrogen bromide; In nitromethane; water; at 70 ℃;

DOI:10.1002/hlca.19920750522

upstream raw materials:

2,4-dibenzyl-4H-oxazol-5-one

L-phenylalanine dimethylamide

N-phenylacetyl-3-phenyl-alanine

Downstream raw materials:

(S)-3-phenyl-2-phenylacetylamino-propionic acid