4-Benzyloxy-1-bromo-naphthalene-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-Benzyloxy-1-bromo-naphthalene-2-carboxylic acid ethyl ester
• CAS No.: 216310-04-2
• Molecular Formula: C₂₀H₁₇BrO₃
• Molecular Weight: 385.257
• Mol file: 216310-04-2.mol

Synonyms:4-Benzyloxy-1-bromo-naphthalene-2-carboxylic acid ethyl ester

Chemical Property of 4-Benzyloxy-1-bromo-naphthalene-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-Benzyloxy-1-bromo-naphthalene-2-carboxylic acid ethyl ester

There total 2 articles about 4-Benzyloxy-1-bromo-naphthalene-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-acetoxynaphthalene-2-carboxylate (33295-46-4) → 4-Benzyloxy-1-bromo-naphthalene-2-carboxylic acid ethyl ester (216310-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / ethanol

2: 1.) NBS, 2.) K₂CO₃ / 1) DMF; 2) DMF

With N-Bromosuccinimide; potassium carbonate; In ethanol;

DOI:10.1021/jo981698q

Reference yield:

ethyl 1,2,3,4-tetrahydro-4-hydroxy-2-naphthoate (91307-39-0) + benzyl bromide (100-39-0) → 4-Benzyloxy-1-bromo-naphthalene-2-carboxylic acid ethyl ester (216310-04-2) + 4-Benzyloxy-1,3-dibromo-naphthalene-2-carboxylic acid ethyl ester

Guidance literature:

With N-Bromosuccinimide; potassium carbonate; Yield given. Multistep reaction. Yields of byproduct given; 1) DMF; 2) DMF;

DOI:10.1021/jo981698q

Reference yield: 94.0%

4-Benzyloxy-1-bromo-naphthalene-2-carboxylic acid ethyl ester (216310-04-2) → (4-Benzyloxy-1-bromo-naphthalen-2-yl)-methanol (216310-06-4)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1021/jo981698q

upstream raw materials:

ethyl 1,2,3,4-tetrahydro-4-hydroxy-2-naphthoate

benzyl bromide

ethyl 4-acetoxynaphthalene-2-carboxylate

Downstream raw materials:

(4-Benzyloxy-1-bromo-naphthalen-2-yl)-methanol

4-Benzyloxy-1-bromo-naphthalene-2-carbaldehyde

1-(4-Benzyloxy-1-bromo-naphthalen-2-yl)-but-3-en-1-ol

5-Benzyloxy-3-methoxy-1-methylene-2,3-dihydro-1H-cyclopenta[a]naphthalene