N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine

Base Information

Chemical Name:N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine
CAS No.:1075215-57-4
Molecular Formula:C₂₀H₁₈Cl₂F₂N₆O
Molecular Weight:467.305
Hs Code.:

Synonyms:N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine

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Chemical Property of N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine

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Technology Process of N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine

There total 4 articles about N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1051899-84-3
2-chloro-N-(3-chloro-2,4-difluoro-phenyl)-N-methyl-pyrimidin-4-amine

: 1075215-73-4
4-chloro-6-(morpholin-4-yl)pyridin-2-amine

: 1075215-57-4
N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine

Guidance literature:: With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; for 15h; Heating / reflux;

Reference yield:

: 1051899-83-2
2-chloro-N-(3-chloro-2,4-difluorophenyl)pyrimidin-4-amine

: 1075215-57-4
N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile

2: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 15 h / Heating / reflux

With potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; acetonitrile;

Reference yield:

: 116632-24-7
2-amino-4,6-dichloropyridine

: 1075215-57-4
N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 0.5 h / 170 °C / Microwave irradiation

2: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 15 h / Heating / reflux

With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dimethyl sulfoxide; toluene;