4-[1-(benzenesulfonyl)cyclopropyl]-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine

Base Information

Chemical Name:4-[1-(benzenesulfonyl)cyclopropyl]-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine
CAS No.:1101819-64-0
Molecular Formula:C₁₈H₂₀ClN₃O₃S
Molecular Weight:393.894
Hs Code.:

Synonyms:4-[1-(benzenesulfonyl)cyclopropyl]-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[1-(benzenesulfonyl)cyclopropyl]-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine

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Technology Process of 4-[1-(benzenesulfonyl)cyclopropyl]-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine

There total 7 articles about 4-[1-(benzenesulfonyl)cyclopropyl]-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1009627-53-5
4-(benzenesulfonylmethyl)-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine

: 106-93-4
ethylene dibromide

: 1101819-64-0
4-[1-(benzenesulfonyl)cyclopropyl]-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In water; at 60 - 70 ℃; for 4h;
DOI:10.1021/jm501778s

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1101819-64-0
4-[1-(benzenesulfonyl)cyclopropyl]-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

4: sodium iodide / 20 h / 50 °C

5: acetonitrile / 20 h / 80 °C / Inert atmosphere

6: tetrabutylammomium bromide; sodium hydroxide / water / 4 h / 60 - 70 °C

With lithium borohydride; tetrabutylammomium bromide; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm501778s

Reference yield:

: 1009628-23-2
(S)-(2-chloro-6-(3-methylmorpholino)pyrimidin-4-yl)methyl methanesulfonate

: 1101819-64-0
4-[1-(benzenesulfonyl)cyclopropyl]-2-chloro-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium iodide / 20 h / 50 °C

2: acetonitrile / 20 h / 80 °C / Inert atmosphere

3: tetrabutylammomium bromide; sodium hydroxide / water / 4 h / 60 - 70 °C

With tetrabutylammomium bromide; sodium iodide; sodium hydroxide; In water; acetonitrile;
DOI:10.1021/jm501778s