3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl fluoride

Base Information

• Chemical Name: 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl fluoride
• CAS No.: 1354060-45-9
• Molecular Formula: C₂₁H₁₉Cl₂FN₂O₂
• Molecular Weight: 421.298
• Mol file: 1354060-45-9.mol

Synonyms:3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl fluoride

Chemical Property of 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl fluoride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl fluoride

There total 9 articles about 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid (1354060-44-8) → 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl fluoride (1354060-45-9)

Guidance literature:

With pyridine; trifluoro-[1,3,5]triazine; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

Reference yield:

1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (851205-62-4) → 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl fluoride (1354060-45-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C

2.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C / Inert atmosphere

5.1: hydrogen / platinum on carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

6.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

6.2: pH 1

7.1: pyridine; trifluoro-[1,3,5]triazine / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

With pyridine; lithium aluminium tetrahydride; trifluoro-[1,3,5]triazine; water; hydrogen; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; lithium chloride; lithium hydroxide; platinum on carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

5-chlorosalicyclaldehyde (635-93-8) → 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl fluoride (1354060-45-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: acetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 17 h / 20 °C / Reflux

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C / Inert atmosphere

7.1: hydrogen / platinum on carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

8.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

8.2: pH 1

9.1: pyridine; trifluoro-[1,3,5]triazine / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

With pyridine; lithium aluminium tetrahydride; trifluoro-[1,3,5]triazine; water; hydrogen; potassium carbonate; Dess-Martin periodane; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; potassium iodide; lithium chloride; lithium hydroxide; platinum on carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

5-chlorosalicyclaldehyde

1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester

1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Downstream raw materials:

N-(3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionyl)-C,C,C-trifluoromethanesulfonamide