N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester
• CAS No.: 913566-75-3
• Molecular Formula: C₁₂H₁₇ClN₂O₃
• Molecular Weight: 272.732
• Mol file: 913566-75-3.mol

Synonyms:N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester

Chemical Property of N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester

There total 5 articles about N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

t-butoxycarbonylhydrazine (870-46-2) + 5-chlorosalicyclaldehyde (635-93-8) → N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester (913566-75-3)

Guidance literature:

t-butoxycarbonylhydrazine; 5-chlorosalicyclaldehyde; With acetic acid; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

N'-[1-(5-Chloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester (478313-95-0) → N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester (913566-75-3)

Guidance literature:

With sodium tris(acetoxy)borohydride;

DOI:10.1016/j.bmcl.2006.06.086

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) → N'-(5-chloro-2-hydroxybenzyl)hydrazinecarboxylic acid tert-butyl ester (913566-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH

2: Na(OAc)3BH

With sodium tris(acetoxy)borohydride; acetic acid;

DOI:10.1016/j.bmcl.2006.06.086

upstream raw materials:

N'-[1-(5-Chloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

t-butoxycarbonylhydrazine

5-chlorosalicyclaldehyde

Downstream raw materials:

1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol

1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde