3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid

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Chemical Name:3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid
CAS No.:1354060-44-8
Molecular Formula:C₂₁H₂₀Cl₂N₂O₃
Molecular Weight:419.307
Hs Code.:

Synonyms:3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid

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Chemical Property of 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid

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Technology Process of 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid

There total 8 articles about 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1354060-43-7
3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid methyl ester

: 1354060-44-8
3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid

Guidance literature:: 3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid methyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 635-93-8
5-chlorosalicyclaldehyde

: 1354060-44-8
3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 17 h / 20 °C / Reflux

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C / Inert atmosphere

7.1: hydrogen / platinum on carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

8.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

8.2: pH 1

With lithium aluminium tetrahydride; water; hydrogen; potassium carbonate; Dess-Martin periodane; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; potassium iodide; lithium chloride; lithium hydroxide; platinum on carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1354060-42-6
(E)-3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-acrylic acid methyl ester

: 1354060-44-8
3-{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / platinum on carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2.2: pH 1

With water; hydrogen; lithium hydroxide; platinum on carbon; In tetrahydrofuran; methanol;