Folinic acid

Base Information

Chemical Name:Folinic acid
CAS No.:58-05-9
Molecular Formula:C20H23N7O7
Molecular Weight:473.445
Hs Code.:
Mol file:58-05-9.mol

Synonyms:Glutamicacid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-,L- (8CI);L-Glutamic acid,N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-(9CI);(6R,S)-5-Formyltetrahydrofolate;5-Formyl-5,6,7,8-tetrahydrofolic acid;5-Formyltetrahydrofolic acid;5-Formyltetrahydropteroylglutamic acid;CF;Folinic acid;Folinic acid-SF;Leucal;Leucoverin;Leucovorin;Levoleucovorin;N5-Formyl-5,6,7,8-tetrahydrofolic acid;N5-Formyltetrahydrofolic acid;Welcovorin;l-Leucovorin;

Suppliers and Price of Folinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
LeucovorinCalciumSalt
1 g
$ 675.00

CSNpharm
FolinicAcid
100mg
$ 55.00

Crysdot
Folinicacid 98+%
1g
$ 740.00

Crysdot
Folinicacid 98+%
250mg
$ 360.00

Crysdot
Folinicacid 98+%
100mg
$ 190.00

Crysdot
Folinicacid 98+%
25mg
$ 80.00

ChemScene
Folinicacid 99.90%
10mg
$ 100.00

ChemScene
Folinicacid 99.90%
5mg
$ 60.00

ChemScene
Folinicacid 99.90%
50mg
$ 250.00

ChemScene
Folinicacid 99.90%
100mg
$ 400.00

Total 78 raw suppliers

Chemical Property of Folinic acid

Chemical Property:

Appearance/Colour:Crystals from water with 3 mol of water of crystallization.
Melting Point:245ºC (decomp)
Refractive Index:1.748
Boiling Point:573.92°C (rough estimate)
PKA:3.1, 4.8, 10.4(at 25℃)
PSA：219.84000
Density:1.68 g/cm³
LogP:1.15290
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Water Solubility.:>1350g/L(25 oC)

Purity/Quality:

99% ^*data from raw suppliers

LeucovorinCalciumSalt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Folinic acid, chemical name N-[4-[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridyl) Methyl]amino]benzoyl-L-glutamic acid has been widely used in cancer combined chemotherapy. Folinic acid enters the human body through the ingestion and absorption pathway of folate. Folinic acid (calcium folinate) is a special form of reduced folic acid (folate).
Uses 1. It is mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.).2. It is used to prevent severe toxic effects caused by methotrexate overdose or high-dose treatment.3. Megaloblastic anemia caused by folic acid deficiency.4. When combined with fluorouracil, it is used to treat advanced colon cancer and rectal cancer. Folinic Acid is used in combination with 5-fluorouracil in the treatment of colorectal cancers. It also functions as a useful antidotal therapy medication for decreasing the toxic effect of methotrexate overdosing.

Technology Process of Folinic acid

There total 28 articles about Folinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6035-45-6
Leucovorin Calcium

: 58-05-9
folinic acid

Guidance literature:: With hydrogenchloride; In water; at 6 - 10 ℃; for 4h; pH=2.8 - 3.2;

Reference yield:

: 58-05-9
folinic acid

Guidance literature:

Reference yield:

: 142811-49-2
N-<4-<<2(S)--3-<(2-amino-5-nitro-4(3H)-oxopyrimidin-6-yl)amino>propyl>amino>benzoyl>-L-glutamic acid

: 58-05-9,22350-60-3,54353-24-1,68538-85-2,73951-54-9
<6S>-N⁵-formyltetrahydrofolic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / aq. 1 M HCl / tetrahydrofuran / 2.5 h / 58 °C

2: 91 percent / hydrogen / 10percent Pd-C / dimethylformamide; aq. HCl / 25 h / 2327.2 Torr

4: 1,1'-carbonyl diimidazole / dimethylformamide

With hydrogenchloride; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; hydrogenchloride; N,N-dimethyl-formamide;
DOI:10.1021/jo00042a030