(2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester

Base Information

• Chemical Name: (2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester
• CAS No.: 219700-40-0
• Molecular Formula: C₃₃H₄₁NO₆
• Molecular Weight: 547.692

Synonyms:(2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester

Chemical Property of (2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester

Chemical Property:

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Technology Process of (2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester

There total 8 articles about (2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

pyruvic acid methyl ester (600-22-6) + Methyl (3S)-3-{N-benzyl-N-[(S)-1-phenylethyl]amino}-6-benzyloxyhexanoate (219700-38-6) → (2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester (219700-40-0) + (2R,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester (219700-39-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(98)02076-0

Reference yield: 30.0%

2-(pent-1-yn-1-yl)aniline (26059-38-1) + thiophenol (108-98-5) → 2-propyl-indole (13228-41-6) + Methyl (3S)-3-{N-benzyl-N-[(S)-1-phenylethyl]amino}-6-benzyloxyhexanoate (219700-38-6) + (2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester (219700-40-0) + (2R,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester (219700-39-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In various solvent(s); at 150 ℃; for 1h;

DOI:10.1016/S0040-4039(98)01998-4

Reference yield: 30.0%

2-(pent-1-yn-1-yl)aniline (26059-38-1) + thiophenol (108-98-5) → 2-((Z)-2-Phenylsulfanyl-pent-2-enyl)-phenylamine + Methyl (3S)-3-{N-benzyl-N-[(S)-1-phenylethyl]amino}-6-benzyloxyhexanoate (219700-38-6) + (3R,4R,5S)-3-Hydroxy-3-methyl-4-methoxycarbonyl-5-(3'-hydroxypropyl)pyrrolidin-2-one (219700-41-1) + (2S,3R)-3-{(S)-4-Benzyloxy-1-[benzyl-((S)-1-phenyl-ethyl)-amino]-butyl}-2-hydroxy-2-methyl-succinic acid dimethyl ester (219700-40-0)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In various solvent(s); at 150 ℃; for 1h;

DOI:10.1016/S0040-4039(98)01998-4

upstream raw materials:

pyruvic acid methyl ester

Methyl (3S)-3-{N-benzyl-N-[(S)-1-phenylethyl]amino}-6-benzyloxyhexanoate

2-(pent-1-yn-1-yl)aniline

thiophenol

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