ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate

Base Information

Chemical Name:ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate
CAS No.:200122-34-5
Molecular Formula:C₂₂H₂₀N₂O₃S
Molecular Weight:392.478
Hs Code.:

Synonyms:ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate

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Chemical Property of ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate

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Technology Process of ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate

There total 18 articles about ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 200122-33-4
ethyl 6-(4-nitrobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate

: 200122-34-5
ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; water; at 25 ℃; Reagent/catalyst; Solvent; Temperature;

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 200122-34-5
ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 50 °C

2: zinc; acetic acid / acetonitrile / 6 h

With dmap; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1127-74-8
1,2,3,4-tetrahydro-5H-benzo[b] azepin-5-one

: 200122-34-5
ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dichloromethane; water / 19.5 h / 18 - 25 °C / Large scale

2.1: trichlorophosphate / 1.5 h / 0 - 5 °C / Large scale

2.2: 19 h / 0 - 80 °C / Inert atmosphere; Large scale

3.1: pyridine; triethylamine / 20 h / 10 - 70 °C / Inert atmosphere; Large scale

4.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / tetrahydrofuran; water; ethanol / 25 °C / Flow reactor

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water;