2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide

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Chemical Name:2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide
CAS No.:1049811-59-7
Molecular Formula:C₃₈H₄₀Cl₂N₆O₃
Molecular Weight:699.68
Hs Code.:

2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide

Synonyms:2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide

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Chemical Property of 2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide

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Technology Process of 2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide

There total 12 articles about 2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1049811-60-0
benzyl-(2-chloro-5-iodo-benzyl)-amine

: 1049809-93-9
2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide

: 1066-54-2
trimethylsilylacetylene

: 1049811-59-7
2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide

Guidance literature:: 2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide; trimethylsilylacetylene; With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; for 18h;

benzyl-(2-chloro-5-iodo-benzyl)-amine; With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; for 24h;

Reference yield:

: 289039-29-8
2-chloro-5-iodobenzonitrile

: 1049811-59-7
2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / toluene / 3.25 h / 0 - 20 °C

1.2: 0 °C

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 18 h

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 18 h

3.2: 24 h

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1049809-92-8
2-[3-(4-chloro-3-iodo-phenyl)-1,4,6,7-tetrahydro-pyrazolo-[4,3-c]pyridin-5-yl]-2-oxo-acetamide

: 1049811-59-7
2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 18 h

2.2: 24 h

With caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide;