2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide

Base Information

Chemical Name:2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide
CAS No.:1049809-93-9
Molecular Formula:C₂₂H₂₇ClIN₅O₃
Molecular Weight:571.846
Hs Code.:

Synonyms:2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide

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Chemical Property of 2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide

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Technology Process of 2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide

There total 8 articles about 2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1049809-92-8
2-[3-(4-chloro-3-iodo-phenyl)-1,4,6,7-tetrahydro-pyrazolo-[4,3-c]pyridin-5-yl]-2-oxo-acetamide

: 1049809-90-6
4-(3-chloro-propyl)-3-methyl-morpholine

: 1049809-93-9
2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 4h;
DOI:10.1021/jo902650b

Reference yield:

: 42860-04-8
4-chloro-3-iodobenzoic acid

: 1049809-93-9
2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 - 17 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

2.2: 16.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 16.33 h / 20 °C

3.2: 3 h / pH > 12

4.1: 1,1'-carbonyldiimidazole / 1,2-dimethoxyethane / 3 h / 20 °C

4.2: 0.5 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

With oxalyl dichloride; caesium carbonate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1049809-93-9
2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / toluene / 16 h / Dean-Stark trap; Heating / reflux

2.1: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

2.2: 16.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 16.33 h / 20 °C

3.2: 3 h / pH > 12

4.1: 1,1'-carbonyldiimidazole / 1,2-dimethoxyethane / 3 h / 20 °C

4.2: 0.5 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

With caesium carbonate; toluene-4-sulfonic acid; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene;