(1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methanol

Base Information

Chemical Name:(1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methanol
CAS No.:917483-14-8
Molecular Formula:C₂₃H₃₀O₂Si
Molecular Weight:366.576
Hs Code.:

Synonyms:(1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methanol

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Chemical Property of (1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methanol

Chemical Property:

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Technology Process of (1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methanol

There total 6 articles about (1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 917483-13-7
(1S,5R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-oxabicyclo[3.1.0]hexan-2-ol

: 1779-49-3
Methyltriphenylphosphonium bromide

: 917483-14-8
(1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methanol

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1080/15257770701508232 DOI:10.1039/b612537a

Reference yield: 20.0%

: 917483-13-7
(1S,5R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-oxabicyclo[3.1.0]hexan-2-ol

: 1779-49-3
Methyltriphenylphosphonium bromide

: 141-78-6
ethyl acetate

: 917483-14-8
(1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methanol

: (1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methyl acetate

Guidance literature:: (1S,5R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-oxabicyclo[3.1.0]hexan-2-ol; Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 3h;

ethyl acetate; In water; Further stages.;
DOI:10.1039/b612537a

Reference yield:

: (1S,5R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-oxa-bicyclo[3.1.0]hexan-2-one

: 917483-14-8
(1R,2S)-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-vinylcyclopropyl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; 2.2: Wittig reaction;
DOI:10.1016/j.bmc.2011.05.026