4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile

Base Information

Chemical Name:4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile
CAS No.:66707-05-9
Molecular Formula:C₁₂H₇F₃N₄O₂
Molecular Weight:296.208
Hs Code.:

Synonyms:4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile

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Chemical Property of 4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile

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Technology Process of 4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile

There total 5 articles about 4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.34%

: 121065-97-2
3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

: 74-88-4
methyl iodide

: 66707-05-9
4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile

Guidance literature:: 3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 0 ℃; for 2h;
DOI:10.1016/j.ejmech.2016.04.062

Reference yield:

: 74-83-9
methyl bromide

: 121065-97-2
3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

: 66707-05-9
4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile

Guidance literature:: With sodium hydride; potassium iodide; In dimethyl sulfoxide; at 70 ℃; for 1h;
DOI:10.1016/j.bmcl.2010.01.116

Reference yield:

: ethyl (Z)-(2-cyano-2-(2-(3-(trifluoromethyl)phenyl)hydrazono)acetyl)carbamate

: 66707-05-9
4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; sodium acetate / 2 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 2 h / 0 °C

With sodium acetate; sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.04.062