3-cyclohexylsalicyl alcohol

Base Information

• Chemical Name: 3-cyclohexylsalicyl alcohol
• CAS No.: 73779-18-7
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.285
• Mol file: 73779-18-7.mol

Synonyms:3-cyclohexylsalicyl alcohol

Chemical Property of 3-cyclohexylsalicyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyclohexylsalicyl alcohol

There total 6 articles about 3-cyclohexylsalicyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-cyclohexylphenol (119-42-6) → 3-cyclohexylsalicyl alcohol (73779-18-7)

Guidance literature:

In 1,2-dimethoxyethane; xylene; at 135 ℃; for 12h;

DOI:10.1055/s-1980-28942

Reference yield:

3-bromosalicyl alcohol isopropylidene acetal (876911-15-8) + cyclohexylmagnesium bromide (931-50-0) → 3-cyclohexylsalicyl alcohol (73779-18-7)

Guidance literature:

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 16h;

DOI:10.1081/NCN-200061791

Reference yield:

3-bromo-2-hydroxybenzyl alcohol (28165-46-0) → 3-cyclohexylsalicyl alcohol (73779-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / p-TsOH; Na₂SO₄ / acetone / 72 h / 40 °C

2: Pd(dppf)Cl₂ / diethyl ether; tetrahydrofuran / 16 h / 20 °C

With toluene-4-sulfonic acid; sodium sulfate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; diethyl ether; acetone; 2: Grignard cross-coupling;

DOI:10.1081/NCN-200061791

upstream raw materials:

2-cyclohexylphenol

3-bromosalicyl alcohol isopropylidene acetal

cyclohexylmagnesium bromide

3-bromo-2-hydroxybenzyl alcohol

Downstream raw materials:

6-tert-Butyl-2-(3-cyclohexyl-2-hydroxy-benzyl)-3-methyl-phenol

C₂₀H₂₄O₂