146578-12-3

Basic information

• Product Name: 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine
• Synonyms: 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine
• CAS NO: 146578-12-3
• Molecular Weight: 771.988
• Mol File: 146578-12-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine(146578-12-3)
• EPA Substance Registry System: 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine(146578-12-3)

Safety Data

• Hazardous Substances Data: 146578-12-3(Hazardous Substances Data)

Upstream product

• 94-36-0 dibenzoyl peroxide 
• 4546-72-9 N₆-benzoyl-2'-deoxyadenosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 

Downstream Products

• 51549-40-7 6-N-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine 
• 583047-57-8 N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2'-deoxy-4'-C-hydroxymethyladenosine 
• 583047-59-0 N⁶-benzoyl-3',5'-di-O-tert-butyldimethylsilyl-4'-C-cyano-2'-deoxyadenosine 
• 583047-58-9 N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 167700-45-0 5'-aldehyde-2'-deoxy-6-N-benzoyl-3'-O-tertbutyldimethylsilyl adenosine 
• 676458-03-0 N⁶-benzoyl-3',5'-di-O-tert-butyldimethylsilyl-4'-C-ethynyl-2'-deoxyadenosine 
• 583047-60-3 N⁶-benzoyl-3',5'-di-O-tert-butyldimethylsilyl-4'-C-cyano-2'-deoxyadenosine 
• 156100-65-1 N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3-oxo-propyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 

Relevant articles and documents

Phosphoramidite nucleoside derivative as well as synthesis method, application and kit thereof

The invention discloses a phosphoramidite nucleoside derivative as well as a synthesis method, application and a kit thereof, and belongs to the field of oligonucleotides. The synthesis method comprises the following steps: protecting hydroxyl of an initiator, protecting N6-site amino on a basic group, and then removing protection of 3 'and 5' hydroxyl to obtain a first intermediate; protecting 5'and 3 'hydroxyl groups of the first intermediate to obtain a second intermediate; removing a protecting group of 5'hydroxyl of the second intermediate, and protecting the 5 'hydroxyl through methoxy isopropyl to obtain a third intermediate; sequentially removing protecting groups of 3'hydroxyl and N6 amino on the basic group in the third intermediate to obtain a fourth intermediate; and carrying out imidization protection on an N6-site amino group on a basic group of the fourth intermediate, and carrying out phosphoramidation protection on a 3 '-hydroxyl group. The method has the advantages of being convenient to implement, economical and capable of achieving large-scale production.

CYCLIC DINUCLEOTIDES AS STING AGONISTS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein B2,X2, R2a, R2b, R2c, Z-M-Y, Y1-M1Z1, B1, X1, R1a, R1b, R1c are as defined herein.

Design, efficient synthesis, and anti-HIV activity of 4′-C-cyano- and 4′-C-ethynyl-2′-deoxy purine nucleosides

Some 4′-C-ethynyl-2′-deoxy purine nucleosides showed the most potent anti-HIV activity among the series of 4′-C-substituted 2′-deoxynucleosides whose 4′-C-substituents were methyl, ethyl, ethynyl and so on. Our hypothesis is that the smaller the substitue