2,2-dimethyl-3-phenyl-N-(quinolin-8-yl)propanamide

Base Information

• Chemical Name: 2,2-dimethyl-3-phenyl-N-(quinolin-8-yl)propanamide
• CAS No.: 1328064-88-5
• Molecular Formula: C₂₀H₂₀N₂O
• Molecular Weight: 304.392
• Mol file: 1328064-88-5.mol

Synonyms:2,2-dimethyl-3-phenyl-N-(quinolin-8-yl)propanamide

Chemical Property of 2,2-dimethyl-3-phenyl-N-(quinolin-8-yl)propanamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2,2-dimethyl-3-phenyl-N-(quinolin-8-yl)propanamide

There total 14 articles about 2,2-dimethyl-3-phenyl-N-(quinolin-8-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

8-amino quinoline (578-66-5) + 2,2-dimethyl-3-phenylpropanoyl chloride (62931-24-2) → 2,2-dimethyl-3-phenyl-N-(quinolin-8-yl)propanamide (1328064-88-5)

Guidance literature:

With potassium hydroxide; In diethyl ether; water; for 0.5h;

DOI:10.1021/acs.organomet.1c00265

Reference yield: 42.0%

N-(2-methylbenzoyl)-8-aminoquinoline (1182669-71-1) + phenyl trimethylsiloxane (2996-92-1,46143-12-8) → 2,2-dimethyl-3-phenyl-N-(quinolin-8-yl)propanamide (1328064-88-5)

Guidance literature:

With copper (II)-fluoride; cobalt(II) acetate; cesium fluoride; at 150 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201806114

Reference yield: 33.0%

α,α,α-trimethyl-N-(quinolin-8-yl)acetamide (170891-76-6) + phenylmagnesium bromide (100-58-3) → 2,2-dimethyl-3-phenyl-N-(quinolin-8-yl)propanamide (1328064-88-5) + 2-benzyl-2-methyl-3-phenyl-N-(quinolin-8-yl)propanamide (1429896-38-7)

Guidance literature:

α,α,α-trimethyl-N-(quinolin-8-yl)acetamide; phenylmagnesium bromide; With N,N,N,N,-tetramethylethylenediamine; zinc dibromide; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With iron(III)-acetylacetonate; 1,2-dichloro-2-methylpropane; o-phenylenebis(diphenylphosphine); In tetrahydrofuran; at 20 - 50 ℃; for 24h;

DOI:10.1021/ja402806f

upstream raw materials:

8-amino quinoline

2,2-dimethyl-3-phenylpropanoyl chloride

benzyl bromide

methyl 2,2-dimethyl-3-phenylpropionate

Downstream raw materials:

C₂₅H₃₀N₂O

C₃₀H₄₀N₂O

3-benzyl-3-methyl-1-(8-quinolinyl)-2-azetidinone

3,3-dimethyl-4-phenyl-1-(8-quinolinyl)-2-azetidinone