ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate

Base Information

• Chemical Name: ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate
• CAS No.: 1365542-27-3
• Molecular Formula: C₂₃H₂₀Cl₂N₄O₃
• Molecular Weight: 471.343
• Mol file: 1365542-27-3.mol

Synonyms:ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate

Chemical Property of ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate

There total 3 articles about ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol (1365542-26-2) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate (1365542-27-3)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 3h; Reflux;

DOI:10.1016/j.jphotochem.2010.11.014

Reference yield:

C19H14Cl2N4O → ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate (1365542-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water

2: potassium carbonate; potassium iodide / acetone / 3 h / Reflux

With hydrogenchloride; potassium carbonate; potassium iodide; In water; acetone;

DOI:10.1016/j.jphotochem.2010.11.014

Reference yield:

3-phenyl-1-(2'-hydroxy-5'-chlorophenyl)-2-propen-1-one (1218-24-2,52923-35-0) → ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate (1365542-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 4.5 h / Reflux

2: hydrogenchloride / water

3: potassium carbonate; potassium iodide / acetone / 3 h / Reflux

With hydrogenchloride; potassium carbonate; potassium iodide; sodium hydroxide; In ethanol; water; acetone;

DOI:10.1016/j.jphotochem.2010.11.014

upstream raw materials:

4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol

chloroacetic acid ethyl ester

3-phenyl-1-(2'-hydroxy-5'-chlorophenyl)-2-propen-1-one

Downstream raw materials:

2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy)acetic acid