2'-Hydroxy-5'-chlorochalcone

Base Information

Chemical Name:2'-Hydroxy-5'-chlorochalcone
CAS No.:1218-24-2
Molecular Formula:C₁₅H₁₁ClO₂
Molecular Weight:258.704
Hs Code.:
Nikkaji Number:J1.073.107K,J461.999D
Wikidata:Q76305813
Metabolomics Workbench ID:73804
ChEMBL ID:CHEMBL2030817
Mol file:1218-24-2.mol

Synonyms:2'-Hydroxy-5'-chlorochalcone;1218-24-2;(E)-1-(5-chloro-2-hydroxyphenyl)-3-phenylprop-2-en-1-one;2-Propen-1-one, 1-(5-chloro-2-hydroxyphenyl)-3-phenyl-;1-(5-chloro-2-hydroxyphenyl)-3-phenylprop-2-en-1-one;Acrylophenone, 5'-chloro-2'-hydroxy-3-phenyl-;1-(5-Chloro-2-hydroxyphenyl)-3-phenyl-2-propen-1-one;52923-35-0;(2E)-1-(5-chloro-2-hydroxyphenyl)-3-phenylprop-2-en-1-one;2-Propen-1-one, 1-(5-chloro-2-hydroxyphenyl)-3-phenyl-, (E)-;Chalcone, 10;CHEMBL2030817;BDBM86010;3-phenyl-1-(2'-hydroxy-5'-chlorophenyl)-2-propene-1-one;(E)-2'-Hydroxy-5'-chlorochalcone;MFCD00180051;STL356142;AKOS022140273;NS-03974;5'-Chloro-2'-hydroxychalcone, AldrichCPR;LS-123846;CS-0334920;(E)-1-(5-chloro-2-hydroxy-phenyl)-3-phenyl-prop-2-en-1-one;(2E)-1-(5-Chloro-2-hydroxyphenyl)-3-phenyl-2-propen-1-one #

Suppliers and Price of 2'-Hydroxy-5'-chlorochalcone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2'-Hydroxy-5'-chlorochalcone

Chemical Property:

Vapor Pressure:3E-08mmHg at 25°C
Boiling Point:437.1°Cat760mmHg
Flash Point:218.2°C
PSA：37.30000
Density:1.292g/cm³
LogP:3.94170
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:258.0447573
Heavy Atom Count:18
Complexity:308

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C=CC(=O)C2=C(C=CC(=C2)Cl)O
Isomeric SMILES:C1=CC=C(C=C1)/C=C/C(=O)C2=C(C=CC(=C2)Cl)O

Technology Process of 2'-Hydroxy-5'-chlorochalcone

There total 9 articles about 2'-Hydroxy-5'-chlorochalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1450-74-4
5-chloro-2-hydroxyacetophenone

: 100-52-7
benzaldehyde

: 1218-24-2,52923-35-0
3-phenyl-1-(2'-hydroxy-5'-chlorophenyl)-2-propen-1-one

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃;
DOI:10.1016/j.tetlet.2014.04.032

Reference yield: 87.9%

: 1450-74-4
5-chloro-2-hydroxyacetophenone

: 100-52-7
benzaldehyde

: 1218-24-2,52923-35-0
5'-chloro-2'-hydroxychalcone

Guidance literature:: 5-chloro-2-hydroxyacetophenone; With sodium hydroxide; In ethanol; water; at 0 ℃; for 0.5h;

benzaldehyde; In ethanol; water; at 0 - 20 ℃; for 12h;
DOI:10.1039/c3ob42429d

Reference yield: 43.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 635-93-8
5-chlorosalicyclaldehyde

: 1218-24-2,52923-35-0
3-phenyl-1-(2'-hydroxy-5'-chlorophenyl)-2-propen-1-one

Guidance literature:: With 1,2,3,4-tetraphenylcyclopentadiene; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; In 1,2-dichloro-ethane; at 120 ℃; for 18h; regioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201203224