4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol

Base Information

• Chemical Name: 4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol
• CAS No.: 1365542-26-2
• Molecular Formula: C₁₉H₁₄Cl₂N₄O
• Molecular Weight: 385.252
• Mol file: 1365542-26-2.mol

Synonyms:4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol

Chemical Property of 4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol

There total 2 articles about 4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H14Cl2N4O → 4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol (1365542-26-2)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1016/j.jphotochem.2010.11.014

Reference yield:

3-phenyl-1-(2'-hydroxy-5'-chlorophenyl)-2-propen-1-one (1218-24-2,52923-35-0) → 4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol (1365542-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 4.5 h / Reflux

2: hydrogenchloride / water

With hydrogenchloride; sodium hydroxide; In ethanol; water;

DOI:10.1016/j.jphotochem.2010.11.014

Reference yield: 83.0%

4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol (1365542-26-2) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate (1365542-27-3)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 3h; Reflux;

DOI:10.1016/j.jphotochem.2010.11.014

upstream raw materials:

3-phenyl-1-(2'-hydroxy-5'-chlorophenyl)-2-propen-1-one

Downstream raw materials:

ethyl 2-(4-chloro-2-(1-(6-chloropyridazin-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy) acetate