Technology Process of 4-chloro-2-(2-chloro-6-nitrophenyl)thiazolo[5,4-c]pyridine
There total 4 articles about 4-chloro-2-(2-chloro-6-nitrophenyl)thiazolo[5,4-c]pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-nitrobenzimidoyl chloride;
With
pyridine; thiourea;
In
isopropyl alcohol;
for 4h;
Inert atmosphere;
Reflux;
With
triethylamine;
In
isopropyl alcohol;
for 16h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 4.67 h / -70 °C
1.2: 2 h / -70 - 20 °C
2.1: potassium phosphate; ethylenediamine / copper(l) iodide / 1,4-dioxane / 4 h / Inert atmosphere; Reflux
3.1: thionyl chloride / 48 h / 85 °C / Inert atmosphere
4.1: thiourea; pyridine / isopropyl alcohol / 4 h / Inert atmosphere; Reflux
4.2: 16 h / Reflux
With
pyridine; potassium phosphate; thionyl chloride; ethylenediamine; thiourea; lithium diisopropyl amide;
copper(l) iodide;
In
tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium phosphate; ethylenediamine / copper(l) iodide / 1,4-dioxane / 4 h / Inert atmosphere; Reflux
2.1: thionyl chloride / 48 h / 85 °C / Inert atmosphere
3.1: thiourea; pyridine / isopropyl alcohol / 4 h / Inert atmosphere; Reflux
3.2: 16 h / Reflux
With
pyridine; potassium phosphate; thionyl chloride; ethylenediamine; thiourea;
copper(l) iodide;
In
1,4-dioxane; isopropyl alcohol;
