3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile

Base Information

Chemical Name:3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile
CAS No.:1365992-73-9
Molecular Formula:C₁₃H₅Cl₂N₃S
Molecular Weight:306.175
Hs Code.:
Mol file:1365992-73-9.mol

Synonyms:3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile

Suppliers and Price of 3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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AK Scientific
3-chloro-2-(4-chlorothiazolo[5,4-c]pyridin-2-yl)benzonitrile
5g
$ 1072.00

Total 1 raw suppliers

Chemical Property of 3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile

Chemical Property:

Purity/Quality:: 3-chloro-2-(4-chlorothiazolo[5,4-c]pyridin-2-yl)benzonitrile ^*data from reagent suppliers

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Technology Process of 3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile

There total 9 articles about 3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: potassium cyanide

: 1365992-80-8
3-chloro-2-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-phenylamine

: 1365992-73-9
3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile

Guidance literature:: 3-chloro-2-(4-chlorothiazolo[5,4-c]pyridin-2-yl)-phenylamine; With hydrogenchloride; sodium nitrite; In water; acetonitrile; at 0 - 5 ℃;

With sodium hydrogencarbonate; In water; acetonitrile; pH=6 - 7;

potassium cyanide; With copper(ll) sulfate pentahydrate; In water; toluene; acetonitrile; at 60 - 70 ℃; for 1.16667h;

Reference yield: 29.0%

: 1365992-72-8
2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine

: copper(l) cyanide

: 1365992-73-9
3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 0.333333h;

Reference yield:

: 148639-07-0
2-chloro-3-fluoro-4-iodopyridyne

: 1365992-73-9
3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

2.1: thionyl chloride / 18 h / 100 °C / Inert atmosphere

3.1: thiourea; pyridine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

3.2: 1.5 h / Reflux

4.1: 1-methyl-pyrrolidin-2-one / 0.33 h / 150 °C

With pyridine; thionyl chloride; caesium carbonate; thiourea; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; isopropyl alcohol;