(S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid

Base Information

Chemical Name:(S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid
CAS No.:1584150-11-7
Molecular Formula:C₁₄H₁₈ClN₃O₆
Molecular Weight:359.766
Hs Code.:

Synonyms:(S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid

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Chemical Property of (S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid

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Technology Process of (S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid

There total 1 articles about (S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 64182-61-2
1-chloro-3-fluoro-2-nitrobenzene

: 76387-70-7
(S)-3-amino-2-tert-butoxycarbonylaminopropionic acid

: 1584150-11-7
(S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid

Guidance literature:: With potassium carbonate; In ethanol; at 80 ℃; for 9h; Inert atmosphere;

Reference yield:

: 1584150-11-7
(S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid

: 1584150-12-8
(S)-3-((2-amino-3-chlorophenyl)amino)-2-((tert-butoxycarbonyl)amino)propanoic acid

Guidance literature:: With ethanol; iron; ammonium chloride; In water; at 80 ℃; for 1.5h;

Reference yield:

: 1584150-11-7
(S)-2-((tert-butoxycarbonyl)amino)-3-((3-chloro-2-nitrophenyl)amino)propanoic acid

: 1584149-66-5
(2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium chloride; ethanol; iron / water / 1.5 h / 80 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 3 h

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / tert-butyl alcohol / 80 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h

5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 2 h

6: trifluoroacetic acid / dichloromethane / 2.5 h

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonia / tetrahydrofuran; isopropyl alcohol / 1.5 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; ammonia; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; XPhos; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;