methyl 4-(1-(5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Base Information

Chemical Name:methyl 4-(1-(5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate
CAS No.:1380754-83-5
Molecular Formula:C₂₇H₂₅ClFN₃O₄
Molecular Weight:509.965
Hs Code.:

Synonyms:methyl 4-(1-(5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

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Chemical Property of methyl 4-(1-(5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

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Technology Process of methyl 4-(1-(5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

There total 5 articles about methyl 4-(1-(5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1014645-87-4
methyl 4-(1-aminocyclopropyl)benzoate hydrochloride

: 1380753-95-6
5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinic acid

: 1380754-83-5
methyl 4-(1-(5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Guidance literature:: 5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinic acid; With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine; at 20 ℃; for 0.5h;

methyl 4-(1-aminocyclopropyl)benzoate hydrochloride; at 20 ℃;

Reference yield:

: 67754-03-4
methyl 2,5-dichloronicotinate

: 1380754-83-5
methyl 4-(1-(5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / methanol / 0.17 h / 150 °C / Microwave irradiation

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 2 h / 0 °C

2.2: 0.67 h / 0 - 20 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

4.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.1 h / 140 °C / Microwave irradiation

5.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / 0.5 h / 20 °C

5.2: 20 °C

With 4-methyl-morpholine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 1380753-14-9
1-(5-chloro-3-(methoxycarbonyl)pyridin-2-yl)azetidine-3-carboxylic acid

: 1380754-83-5
methyl 4-(1-(5-chloro-2-(3-((4-fluorophenoxy)methyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 2 h / 0 °C

1.2: 0.67 h / 0 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.1 h / 140 °C / Microwave irradiation

4.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / 0.5 h / 20 °C

4.2: 20 °C

With 4-methyl-morpholine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; water;